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KMID : 0364219760190040161
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Korean Journal of Zoology
1976 Volume.19 No. 4 p.161 ~ p.170
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On the Possible Interaction of Caffeine with the Fragmented Sarcoplasmic Reticulum of Rabbit Skeletal Muscle
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Ha Doo-Bong
Kim Han-Do
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Abstract
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Since caffeine inhibits the active uptake of Ca by the sarcoplasmic reticulum, the action of caffeine on the fragmented sarcoplasmic reticulum of rabbit skeletal muscle was studied. Caffeine seemed not to bind tightly to the sarcoplasmic reticulum. The determination of sulfhydryl content of the fragmented sarcoplasmic reticulum, however, suggested that caffeine in some unknown manner influences the protein moiety and thereby increases the sulfhydryl content. The inhibition of Ca uptake by caffeine therefore might be considered as due to the result of this change in protein sulfhydryl content.
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